ParkinsonV1, Main, Exploration, bibRecord, 002C58

Levodopa alone and in combination with a peripheral decarboxylase inhibitor benserazide (madopar®) in the treatment of Parkinson's disease

Identifieur interne : 002C58 ( Main/Exploration ); précédent : 002C57; suivant : 002C59

Levodopa alone and in combination with a peripheral decarboxylase inhibitor benserazide (madopar®) in the treatment of Parkinson's disease

Auteurs : K. Rinne [Finlande] ; E. Birket-Smith [Danemark] ; E. Dupont [Danemark] ; E. Hansen [Danemark] ; M. Hyypp [Finlande] ; R. Marttila [Finlande] ; B. Mikkelsen [Danemark] ; H. Pakkenberg [Danemark] ; J. Presthus [Norvège]

Source :

Journal of Neurology [ 0340-5354 ] ; 1975-12-01.

RBID : ISTEX:314E4884A0A407BF44E68BEBA1A795FD9AED199B

Abstract

Summary: A combination of levodopa and the extracerebrally acting decarboxylase inhibitor benserazide (ratio 4:1) (Madopar®), was compared with levodopa alone in a controlled double-blind clinical multicenter trial on 94 patients with Parkinson's disease. During 4 months of therapy levodopa + benserazide proved superior to levodopa on several accounts. Nausea and vomiting occurred with statistically significant less severity and frequency. Clinical improvement expressed through improvement in Webster rating occurred sooner and was all together greater. The treatment schedules did not differ with regard to other side effects, in particular involuntary movements and reduction in supine blood pressure. Neither treatment seemed to influence liver function, renal function and hematological parameters.

Url:

https://api.istex.fr/document/314E4884A0A407BF44E68BEBA1A795FD9AED199B/fulltext/pdf

DOI: 10.1007/BF00312459

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Summary: A combination of levodopa and the extracerebrally acting decarboxylase inhibitor benserazide (ratio 4:1) (Madopar®), was compared with levodopa alone in a controlled double-blind clinical multicenter trial on 94 patients with Parkinson's disease. During 4 months of therapy levodopa + benserazide proved superior to levodopa on several accounts. Nausea and vomiting occurred with statistically significant less severity and frequency. Clinical improvement expressed through improvement in Webster rating occurred sooner and was all together greater. The treatment schedules did not differ with regard to other side effects, in particular involuntary movements and reduction in supine blood pressure. Neither treatment seemed to influence liver function, renal function and hematological parameters.</div>
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Levodopa alone and in combination with a peripheral decarboxylase inhibitor benserazide (madopar®) in the treatment of Parkinson's disease

Levodopa alone and in combination with a peripheral decarboxylase inhibitor benserazide (madopar®) in the treatment of Parkinson's disease

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri